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The morphometic surveies in bosom in relation to age and sex and other parametric quantities including weight, size, aorta, pneumonic bole, pericardium, myocardium & A ; endocardium have been done in yesteryear but the information in this portion of the universe is missing it will give valuable information for the anatomists, doctors and cardiac sawboness

Coronary anomalousnesss although non really common but their incidence with or with out other inborn bosom diseases are once more really enlightening. The latest information on the above findings are yet to be scientifically collected in this portion of the universe.

Coronary arteria disease is a major cause of human mortality and morbidity. It is besides established that the incidence of coronary arteria disease is much higher in work forces than in adult females until the 4th 5th decennaries of life when it increases more steeply in adult females than in work forces ( Kalin and Zumoff, 1990 ) . The grounds for this difference are, nevertheless, non to the full understood. It has been speculated that the protective factor may be the female endocrine estrogen which favorably affects lipid metamorphosis decelerating down the procedure of coronary artery disease in coronary arterias ( Walsh et al. , 1991 ) . It is good known that blood flow through arterias is influenced by assorted mechanical and hydraulic factors ( Braunwald, 1992 ) , but sex differences in morphometric characteristics of coronaries like diameter and wall thickness do non look to hold attracted much attending as evidenced by dearth of publications. The present survey is, hence aimed to analyze histomorphometric characteristics of coronary arterias which may add to the apprehension of sexual differences in coronary arteria disease.

In the past surveies of lipoid in tunica intima of arterias have been done by Gross et Al ( 1934 ) , Harvey et Al ( 1963 ) , Spiro and Wiener ( 1963 ) .Clarification of relationship of systemic blood force per unit area with coronary artery disease has besides been tried by Anitschkow ( 1913 ) , Turnbull ( 1915 ) , Davis and Klainer ( 1940 ) , Bronte and Heptinstall ( 1954 ) , Morgan ( 1956 ) , Heptinstall et Al ( 1958 ) , Wilkins et Al. ( 1959 ) Paterson et Al, ( 1960 ) and Sacks ( 1960 ) .

Kumar ( 1996 ) reported the increasing pulse force per unit area of blood as a cause of arterial coronary artery disease. Kumar ( 2003 ) calculated pulsation

force per unit areas of blood in left and right human coronary arterias. But exact anatomy of human coronary arterial lipid accretion was unsure to smoke, alcohol addiction, anxiousness and high blood pressure.

Because arterial coronary artery disease begins with the increasing denseness of lipoid in adventitia intima, hence, the present survey is conducted to compare densenesss of adventitia intimal lipid interrelating with pulse force per unit areas of blood in these arterias.

Hypothesis

For the present survey we proposed the void hypothesis that there is no important difference in the morphology of bosom and form of distribution of coronary vass and coronary artery disease in different sexes in our population in comparing to western population

STUDY OBJECTIVES

To set up comprehensive morphological parametric quantities of bosom and to find correlativity of distribution of coronary vass in both sexes with accent coronary artery disease in our population.

STUDY BENEFITS

By the analysis of anatomical fluctuation in bosom and form of coronaries we can precisely sketch the prognostic morphology and form of vasculature of human bosom in our population.This would be of extreme importance and add to the bing groups in scientific information ‘s from this portion of the universe.

MATERIALS AND METHODS

Samples of Black Marias will be obtained from the pathology section of D.U.H.S and morgues of DOW Medical Collage & A ; Sindh Medical Collage. We will analyse the cardiac size, weight, myocardial thickness, influx and outflow channels related to valves, go uping aorta and coronary vass ( there anomalies & A ; atherosclerotic position ) .

SAMPLES SIZE

The survey will include 200 bosom samples.

STUDY DESIGN

This will be descriptive comparative survey

INCLUSION CRITERIA

All those necropsies performed to determine cause of decease in medicoleagal instances would be included as unselected series.

Statistical Analysis

Statistical analysis utilizing SPSS version 10.0 ( statistical bundle for the societal scientific disciplines, Chicago, Illinois, USA ) will be done to happen out standard divergence ( S.D ) pupil ‘t ‘ trial and Chi-square trial will be used to happen the value of ‘P. P 0.05 will be see important.

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